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The Evaluation of Memantine Effect on Tinnitus Severity
Babak Pourayyoubi1, Alireza Rezaei-Ashtiani2, Javad Javaheri3
1Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Brain and Behavior
|July 21, 2025
Summary
Memantine significantly reduced tinnitus severity and discomfort in patients. This study suggests memantine as a promising treatment for tinnitus, improving outcomes measured by the Tinnitus Severity Index.
Area of Science:
- Neurology
- Otolaryngology
- Pharmacology
Background:
- Tinnitus involves perceiving sound without external stimuli, often linked to NMDA receptor overactivity and excitotoxicity.
- NMDA receptor antagonists like memantine show potential for tinnitus treatment.
Purpose of the Study:
- To evaluate the efficacy of memantine in treating tinnitus.
- To conduct a double-blind, randomized, placebo-controlled clinical trial on memantine for tinnitus.
Main Methods:
- 70 tinnitus patients were randomized into two groups: intervention (memantine + cinnarizine) and placebo (cinnarizine only).
- Both groups received cinnarizine 25 mg twice daily; the intervention group additionally received memantine starting at 5 mg.
- Tinnitus Severity Index (TSI) and Numeric Rating Scale (NRS) were assessed pre- and post-treatment.
Main Results:
- No significant baseline differences in NRS and TSI scores between groups.
- Post-treatment, both NRS and TSI scores significantly decreased in the memantine intervention group.
- While NRS scores improved in both groups, only TSI scores showed a significant reduction in the intervention group.
Conclusions:
- Memantine demonstrates a notable effect in alleviating tinnitus symptoms and associated discomfort.
- Findings suggest memantine as a potentially effective therapeutic agent for managing tinnitus.
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