Related Experiment Video
Updated: Sep 14, 2025

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Exploring norfloxacin analogs in combating antimicrobial resistance: design, mechanistic insights and structure
Aanchal Khanna1, Karanvir Singh1, Jyoti1
1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Abstract:
Norfloxacin (NF), a fluoroquinolone (FN) antibiotic, has garnered significant attention for its broad-spectrum antimicrobial activity, particularly against gram-negative bacteria. This review article explores the structural modifications and derivatives of NF that enhance its efficacy and broaden its antimicrobial spectrum. We systematically analyze various chemical modifications, including substitutions at the 7 and 8 positions of the quinolone core, and their impact on antibacterial potency, pharmacokinetics, and resistance profiles. Additionally, we discuss the mechanisms of action of NF derivatives, their effectiveness against resistant strains, and the potential for synergistic combinations with other antimicrobial agents. The review highlights promising candidates from recent studies, emphasizing the need for continued research into NF derivatives as potential therapeutic options in the fight against multidrug-resistant infections. Ultimately, this article aims to provide a comprehensive overview of the advancements in NF derivatives, contributing to the development of novel antimicrobial strategies.
More Related Videos
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Development of Antibiotic Resistance
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Antibiotic Selection
Drug Discovery: Overview
Gene Regulation in Microbial Communities: Quorum Sensing

