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Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance.

Peng Chen¹, Shaphan Jernigan¹, Keren Zhao¹

¹Department of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC, USA. jhu35@ncsu.edu.

Biomaterials Science

|July 21, 2025

Summary

This summary is machine-generated.

Researchers developed new radiopaque microspheres for transcatheter arterial embolization (TAE). These tantalum-loaded calcium alginate microspheres offer improved imaging and control for treating vascular conditions.

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Area of Science:

Biomaterials Engineering
Interventional Radiology
Medical Imaging

Background:

Transcatheter arterial embolization (TAE) utilizes embolic agents, but current microspheres often lack radiopacity and optimal properties.
Limitations include unpredictable trajectories, non-target delivery, and suboptimal embolization, impacting treatment efficacy.

Purpose of the Study:

To develop novel tantalum-loaded calcium alginate (Ta@Ca-Alg) microspheres with intrinsic radiopacity, tunable density, and mechanical properties.
To evaluate the synthesized microspheres for their suitability as advanced embolic agents in TAE procedures.

Main Methods:

Ta@Ca-Alg microspheres were synthesized using a gas-shearing method.
Characterization included size, morphology, swelling, density, radiopacity, and mechanical property analysis.
In vitro hemocompatibility, sterility, cytotoxicity, and phantom model testing were performed.

Main Results:

Ta@Ca-Alg microspheres exhibited narrow size distribution and enhanced radiopacity with increasing tantalum concentration, comparable to clinical contrast agents.
Tunable density and Young's modulus were achieved.
Phantom models demonstrated effective vessel occlusion and controlled penetration, with excellent biocompatibility confirmed in vitro.

Conclusions:

Ta@Ca-Alg microspheres represent a promising radiopaque embolic agent with optimized physical properties for TAE.
These novel microspheres offer significant potential for improved precision and outcomes in embolization procedures.