Related Experiment Video
Updated: Sep 14, 2025

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
Muhenrins A-C, pimarane-type diterpenoids from Munronia henryi
Wan-Bai Su1, Xiao-Meng Hou1, Ling Zhang1
1a, School of Pharmacy, Anhui University of Chinese Medicine, Anhui Province Key Laboratory of Bioactive Natural Products Hefei 230012 P.R. China sunyp@ahtcm.edu.cn wanggk@ahtcm.edu.cn.
None:
Three undescribed pimarane-type diterpenoids, muhenrins A-C (1-3), along with a known analogue were isolated from the petroleum ether extract of Munronia henryi (Meliaceae). Their structures, including absolute configurations, were elucidated by means of various spectroscopic methods (IR, UV, HR-ESI-MS, NMR), single-crystal X-ray diffraction, ECD and NMR calculations. Muhenrin A (1) features a unique 6,7-seco pimarane skeleton, and its putative biosynthetic pathways have been proposed. Compounds 1-4 showed weak inhibitory activity against NO production in LPS-induced RAW 264.7 cells, with inhibition rates ranging from 13.73 - 32.35% at 50 μM concentrations.
Related Concept Videos
Physical Properties of Amines
Antiasthma Drugs: Muscarinic Receptor Antagonists
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antihypertensive Drugs: Direct Renin Inhibitors
Nomenclature of Aryl and Heterocyclic Amines
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction

