Related Experiment Video

Updated: Sep 14, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

32.6K

Antibiotic prophylaxis may be still required among transperineal prostate biopsies of diabetics: a cohort study

Feiyue Ma1, Yu Zhang1

  • 1Department of Urological Surgery, Xiangshan County First People's Hospital Medical Health Group, Zhejiang, China.

Frontiers in Medicine
|July 21, 2025
PubMed
Abstract

Insights

Antibiotic prophylaxis significantly reduced urinary tract infections and related symptoms in diabetic patients undergoing transperineal prostate biopsy. This preventive measure is crucial for improving patient outcomes after the procedure.

Area of Science:

  • Urology
  • Infectious Diseases
  • Oncology

Background:

  • Transperineal prostate biopsy (TP-PB) is a standard procedure for diagnosing prostate cancer.
  • TP-PB carries a risk of urinary tract infections (UTIs), with reported rates up to 3%.
  • Diabetic patients may be at increased risk for infections following invasive procedures.

Purpose of the Study:

  • To investigate the incidence of TP-PB-related infections in diabetic patients.
  • To compare infection rates between diabetic patients who received antibiotic prophylaxis (AP) and those who did not.

Main Methods:

  • A monocentric, comparative, observational cohort study included 246 diabetic men undergoing TP-PB.
  • Patients were divided into two groups: no antibiotic prophylaxis (n=120) and 3-day oral antibiotic prophylaxis (n=126).
  • Data collected included symptoms, urine cultures, UTI incidence, and biopsy-related sequelae within two weeks post-biopsy.

Main Results:

  • The group receiving antibiotic prophylaxis showed significantly lower rates of asymptomatic bacteriuria (0.8% vs. 6.7%), urinary irritation symptoms (4.0% vs. 25.0%), fever (0.8% vs. 7.5%), and UTIs (0.8% vs. 4.2%) compared to the no-AP group.
  • No cases of sepsis were reported in either group.
  • Prostate-specific antigen levels and prostate cancer detection rates were similar between the groups.

Conclusions:

  • Antibiotic prophylaxis is effective in reducing the incidence of transperineal prostate biopsy-related infections in diabetic patients.
  • The findings support the use of AP to mitigate infection risks associated with TP-PB in this patient population.
Keywords:
antibiotic prophylaxisdiabetic patientsprostate cancertransperineal prostate biopsyurinary tract infections

More Related Videos

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

457
Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

21.7K

Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
41
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
41
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
262