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Related Experiment Videos

Is serum selenium a risk factor for cancer?

I Peleg, S Morris, C G Hames

    Medical Oncology and Tumor Pharmacotherapy
    |January 1, 1985
    PubMed
    Summary

    High esophageal cancer rates in non-white males were observed along the southeastern Atlantic coast. A study found no link between low selenium levels and subsequent cancer risk in this region.

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    Area of Science:

    • Epidemiology
    • Environmental Health
    • Nutritional Science

    Background:

    • Elevated esophageal cancer incidence in non-white males identified in a specific southeastern Atlantic coastal region (Jacksonville, FL to Charleston, SC).
    • Lung cancer rates are higher in white males in the same region, while non-white males show average rates.
    • Selenium's potential role in cancer risk reduction is recognized from animal studies.

    Purpose of the Study:

    • To investigate the relationship between baseline serum selenium levels and the risk of developing cancer in a high-incidence coastal region.

    Main Methods:

    • A cohort of 130 cancer patients from the identified coastal region were analyzed.
    • Baseline serum selenium levels were measured.
    • Cancer development was tracked 2-12 years after the baseline examination.

    Main Results:

    • No dose-response relationship was found between baseline serum selenium levels and the risk of developing subsequent cancer.
    • This finding contrasts with the potential cancer-protective effects suggested by animal models.

    Conclusions:

    • Baseline serum selenium levels do not appear to be a significant factor in the risk of developing cancer in this specific high-incidence coastal population.
    • Further research may be needed to explore other environmental or genetic factors contributing to the observed cancer disparities.

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