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Single Strain vs Multiple Strain Probiotics: The Clinician's Choice.
Dhanasekhar Kesavelu1, Arunchander Yadav Krishnamurty2, Priya A2
1Paediatric Gastroenterology, Apollo Children's Hospital, Chennai, IND.
Cureus
|July 21, 2025
Summary
Pediatricians increasingly prescribe probiotics for children, with a strong preference for single-strain options like Bacillus clausii. This study analyzed 22,500 prescriptions, revealing trends in probiotic use for pediatric health.
Area of Science:
- Pediatrics
- Microbiome Research
- Pharmacology
Background:
- Growing interest in probiotics for optimizing intestinal health in children and adults.
- Increasing use of probiotics in pediatric clinical practice due to scientific evidence.
- Probiotics are considered for therapeutic and preventive roles in various diseases.
Purpose of the Study:
- To prospectively analyze probiotic prescription patterns among pediatricians.
- To identify preferred probiotic strains and formulations in a pediatric tertiary care setting.
Main Methods:
- Prospective, observational study at a single tertiary care center.
- Involved 53 pediatricians and analysis of 22,500 prescriptions from electronic medical records (EMR).
- Data collected for children aged 0 to 16 years.
Main Results:
- Single-strain probiotic prescriptions constituted 77.20% (17,370/22,500) of all analyzed prescriptions.
- Bacillus clausii was the most frequently prescribed single-strain probiotic (48.57%).
- A common multi-strain combination included Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, and Lactobacillus sporogenes (37.85%).
Conclusions:
- Pediatricians demonstrate a significant preference for single-strain probiotics.
- Bacillus clausii emerged as the leading single-strain probiotic choice.
- The findings highlight specific prescription trends in pediatric probiotic use.
