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Updated: Sep 14, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
ANCA-Negative Microscopic Polyangiitis With Gastrointestinal and Renal Involvement: A Diagnostic and Therapeutic
Devon D Thorpe1, Shahtaj Shah1, Ekene Okeke1
1Internal Medicine, Overlook Medical Center, Summit, USA.
Abstract:
We present the case of a 64-year-old male with acute kidney injury (AKI) and gastrointestinal symptoms. Computed tomography (CT) revealed inflammatory changes in the lungs and colon, and push enteroscopy confirmed enteritis. Initially, AKI was attributed to GI losses causing prerenal azotemia, but persistent proteinuria prompted kidney biopsy, confirming anti-neutrophil cytoplasmic antibody (ANCA)-negative microscopic polyangiitis (MPA). While induction immunosuppression was planned, the patient developed necrotizing fasciitis requiring treatment deferral. Renal function ultimately normalized with steroids alone, highlighting the need for individualized therapy in seronegative vasculitis. This case underscores the diagnostic challenge of ANCA-negative MPA and the pivotal role of histopathology and multidisciplinary collaboration.
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