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Asymmetrical Auditory Dysfunction as a Potential Nonmotor Lateralizing Sign in Parkinson's Disease: A Case-Control
Reham Mamdouh Lasheen1, Mohamed Nasser Elsheikh2, Mohamed Osama Tomoum3
1Assistant Professor of Audiovestibular Medicine, Faculty of Medicine, Tanta University, Egypt.
Summary
Auditory dysfunction is common in Parkinson's disease (PD), often showing asymmetry. This lateralized auditory impairment may serve as a valuable biomarker for diagnosing PD and understanding its impact on sensory systems.
Area of Science:
- Neurology
- Audiology
- Neuroscience
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms, but nonmotor symptoms like auditory dysfunction significantly affect quality of life.
- Auditory dysfunction is increasingly recognized as a feature of PD, impacting patient well-being.
Purpose of the Study:
- To evaluate auditory impairment in PD patients.
- To assess the asymmetry of auditory dysfunction as a potential biomarker for differentiating PD from other neurodegenerative disorders.
Main Methods:
- Included 60 patients with parkinsonism and 40 healthy controls.
- Utilized pure tone audiometry (PTA), auditory brainstem response (ABR), and otoacoustic emissions (OAE) for auditory testing.
Main Results:
- PD patients exhibited significantly higher PTA thresholds, especially on the affected side.
- ABR latencies were delayed in PD patients, more pronounced on the affected side.
- Distortion product OAE amplitudes were significantly reduced in PD patients, particularly on the affected side, and lower than in controls.
Conclusions:
- The asymmetry of audiological responses in PD patients is a significant finding.
- This lateralized auditory dysfunction can be a valuable nonmotor marker for PD.
- It aids in understanding PD's impact on sensory systems and may improve diagnosis and monitoring.
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