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OCIAD2 Promotes Cancer Progression via Metabolic Reprogramming in Lung Adenocarcinoma

Yi-Hui Huang1,2, Wen-Hsin Chang3, Chi-Ya Shen1

  • 1Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.

Journal of Proteome Research
|July 21, 2025
PubMed

Insights

Lung adenocarcinoma progression is linked to the protein OCIAD2. This study found OCIAD2 promotes cancer growth by altering cell metabolism, suggesting it as a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Lung adenocarcinoma has a high incidence and limited proteomic understanding.
  • Uncharacterized proteins are critical for understanding cancer progression.
  • OCIAD2 (OCIA domain-containing 2) was identified as upregulated in lung adenocarcinoma.

Purpose of the Study:

  • To investigate the role of OCIAD2 in lung adenocarcinoma progression.
  • To explore OCIAD2's impact on cell migration, invasion, and colony formation.
  • To determine OCIAD2's involvement in cellular metabolism and its effect on oxidative phosphorylation.

Main Methods:

  • Proteogenomic analysis of the Taiwan Cancer Moonshot cohort.
  • Gene silencing of OCIAD2 in lung adenocarcinoma cells.
  • Gene Set Enrichment Analysis (GSEA).
  • Mitochondrial metabolic assays.

Main Results:

  • OCIAD2 was highly expressed in 95.5% of lung adenocarcinoma tumor tissues.
  • Elevated OCIAD2 expression correlated with worse patient survival.
  • OCIAD2 silencing reduced cell migration, invasion, and colony formation.
  • OCIAD2 impairs oxidative phosphorylation (OXPHOS) and promotes glycolysis.

Conclusions:

  • OCIAD2 promotes lung adenocarcinoma progression via metabolic reprogramming.
  • OCIAD2 functions as a potential biomarker for lung adenocarcinoma.
  • OCIAD2 represents a potential therapeutic target for lung adenocarcinoma.
Keywords:
Chromosome-centric Human Proteome ProjectLung adenocarcinomaOvarian Cancer Immunoreactive Antigen Domain Containing 2Uncharacterized protein existence level 1

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