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Related Experiment Video

Updated: Sep 14, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Microbiome and gartynecologic cancer.

Bingqing Liao¹, Liang Chen¹, Jinghan Ruan²

¹Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China.

|July 22, 2025

Summary

The female reproductive tract microbiota, dominated by lactobacilli, influences gynecological cancers. Imbalances in this microbiome can promote cervical, endometrial, and ovarian cancer development and progression.

Keywords:

Cervical cancer Endometrial cancer Gynecological cancers Microbiota Multi-omics technologies Ovarian cancer

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Area of Science:

Microbiome research
Gynecologic oncology
Immunology

Background:

The female reproductive tract harbors a unique microbiota, typically dominated by lactobacilli.
Lactobacilli maintain a healthy microenvironment through lactic acid production.
Microbial dysbiosis is increasingly linked to inflammation and gynecological cancer development.

Purpose of the Study:

To review the relationship between the microbiota and cervical, endometrial, and ovarian cancers.
To explore the role of microbes in the prevention, diagnosis, and treatment of these cancers.
To discuss the application of multi-omics in microbial studies and future research directions.

Main Methods:

Literature review focusing on microbial roles in gynecological cancers.
Analysis of multi-omics techniques applied to microbial research.
Synthesis of current knowledge on microbial characteristics in gynecological cancers.

Main Results:

Microbial imbalances can drive gynecological cancer by altering immune responses, metabolites, and hormone levels.
Specific microbial profiles are associated with cervical, endometrial, and ovarian cancers.
Multi-omics approaches offer insights into complex host-microbe interactions.

Conclusions:

The gynecological microbiota is a critical factor in cancer development and progression.
Targeting the microbiome holds potential for novel strategies in cancer prevention, diagnosis, and treatment.
Further research is needed to address current challenges and explore future therapeutic avenues.