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Synovial Fluid Analysis to Identify Osteoarthritis
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[SAPHO-Synovitis, acne, pustulosis, hyperosteosis, osteitis].

N Hesse1, B Hoppe2, P Reidler2

  • 1Klinik und Poliklinik für Radiologie, LMU München, Ziemssenstraße 5, 80336, München, Deutschland. Nina.hesse@med.uni-muenchen.de.

Radiologie (Heidelberg, Germany)
|July 22, 2025
PubMed
Summary
This summary is machine-generated.

Synovitis, acne, pustulosis, hyperosteosis, and osteitis (SAPHO) syndrome diagnosis is often delayed. Whole-body MRI aids early, noninvasive detection of active disease, complementing traditional imaging methods for this rare condition.

Keywords:
Cutibacterium acnesMusculoskeletal lesionsPustulosis palmoplantarisSkin manifestationsSterile osteomyelitis

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Area of Science:

  • Rheumatology
  • Medical Imaging
  • Dermatology

Context:

  • SAPHO syndrome presents with complex osteoarticular and dermatological symptoms, often leading to diagnostic delays.
  • Nonsimultaneous manifestation of symptoms complicates early identification of this rare rheumatological condition.
  • Accurate diagnosis relies on identifying characteristic bone changes and differentiating from other conditions.

Purpose:

  • To evaluate the role of advanced imaging techniques in diagnosing SAPHO syndrome.
  • To compare the efficacy of whole-body MRI with conventional imaging modalities.
  • To highlight the importance of imaging in the early and accurate diagnosis of SAPHO syndrome.

Summary:

  • Established methods like X-ray, CT, and scintigraphy detect osseous changes in SAPHO syndrome.
  • Magnetic resonance imaging (MRI) enables early detection of inflammatory bone and soft tissue alterations.
  • Whole-body MRI systematically identifies multifocal lesions and differentiates active from inactive disease without radiation, offering an advantage over scintigraphy.

Impact:

  • Whole-body MRI is a valuable, noninvasive tool for assessing active SAPHO syndrome disease processes.
  • It enhances diagnostic capabilities, particularly in early disease detection and evaluation.
  • Integrating whole-body MRI into diagnostic protocols improves the management of SAPHO syndrome.