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Updated: Sep 14, 2025

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Tumor-Embedded Nerve Surgery Using Dual-Channel Intraoperative Imaging Probes.

Eun Bi Jun1,2,3, Kyungsu Kim1,2,3, Jun Hee Lee1,2,3

  • 1Department of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, College of Medicine, Korea University, Seoul 08308, Republic of Korea.

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Summary

A new nerve-specific near-infrared (NIR) fluorophore, NTFP700, allows for precise nerve imaging during cancer surgery. This method, combined with a tumor agent, helps surgeons differentiate nerves and tumors, reducing injury risk.

Keywords:
cancer targetingdual-channel imagingdyed gauze methodfluorescence contrast agentnerve imaging

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Area of Science:

  • Surgical Oncology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Nerve identification during cancer surgery is challenging due to anatomical shifts, increasing injury risk.
  • Nerve damage can cause severe complications like chronic pain and motor dysfunction.
  • Existing intravenous contrast agents carry systemic side effect risks.

Purpose of the Study:

  • To develop and evaluate a nerve-specific near-infrared (NIR) fluorophore, NTFP700, for local application.
  • To assess NTFP700's ability to selectively image nerves.
  • To explore a dual-channel NIR imaging approach for differentiating nerves and tumors.

Main Methods:

  • Development of NTFP700, a nerve-specific NIR fluorophore for 700 nm imaging.
  • Application of NTFP700 using a dyed-gauze method for enhanced visualization.
  • Dual-channel NIR imaging combining NTFP700 with a tumor-targeted agent (cRGD-ZW800-PEG, 800 nm).

Main Results:

  • NTFP700 effectively highlighted nerve structures with strong fluorescence.
  • The dyed-gauze method improved visualization of anatomically altered nerves.
  • Dual-channel imaging successfully distinguished nerves from tumors using distinct fluorescent signals.

Conclusions:

  • NTFP700 shows potential as a nerve-targeting fluorophore for local application in surgery.
  • Combining NTFP700 with a tumor agent and dyed-gauze method offers a promising strategy for nerve-tumor differentiation.
  • This approach may reduce nerve-related complications in oncological procedures.