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Epigenetic Regulation and Targeted Therapy in Gall Bladder Cancer

Devbrat Singh1, Sayali Mukherjee1

  • 1Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Lucknow, India.

Journal of Biochemical and Molecular Toxicology
|July 23, 2025
PubMed

Insights

Epigenetic alterations like DNA methylation are key in gall bladder cancer development. Targeting these epigenetic changes offers new diagnostic, prognostic, and therapeutic strategies for this aggressive cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Gall bladder cancer is aggressive, often diagnosed late.
  • Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA alterations, are increasingly recognized in cancer development.
  • Personalized and targeted therapies are revolutionizing cancer treatment.

Purpose of the Study:

  • To review the role of epigenetic markers in gall bladder cancer.
  • To explore the diagnostic and prognostic potential of epigenetic alterations.
  • To discuss novel therapeutic targets and advancements in targeted therapies for gall bladder cancer.

Main Methods:

  • Literature review focusing on epigenetic pathways in gall bladder cancer.
  • Analysis of current research on diagnostic and prognostic epigenetic markers.
  • Examination of recent advancements in targeted therapies and precision medicine.

Main Results:

  • Epigenetic markers show significant potential for early diagnosis and prognosis in gall bladder cancer.
  • Targeted therapies are proving effective, with advancements tailored to gall bladder cancer.
  • Precision medicine approaches are crucial for customizing treatment based on individual patient profiles.

Conclusions:

  • Epigenetic modifications are critical drivers in gall bladder cancer.
  • Epigenetic markers offer promising avenues for improved diagnostics and prognostics.
  • Targeted therapies focusing on epigenetic changes hold potential for more effective and less toxic treatments.
Keywords:
epigenetic regulationgall bladder cancerprecision medicinetargeted therapies

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