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Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis
Katie Ridge1,2, Barry Moran3, Mark A Little2,4
1UCARE Centre, Clinical and Diagnostic Immunology, St. James's Hospital, Dublin, Ireland.
Summary
Researchers found increased myeloid progenitors in the blood of individuals with atopic dermatitis (AD). These cells may play a role in AD pathogenesis and could be linked to increased bone marrow egress in atopy.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin disease.
- Mast cells contribute to AD pathogenesis through proinflammatory mediators.
- Myeloid and mast cell progenitors are potential biomarkers for treatment response in chronic spontaneous urticaria.
Purpose of the Study:
- To investigate the presence and role of myeloid progenitors in atopic dermatitis.
- To determine if myeloid progenitors (Lin-CD117+CD34+FceRI+) are increased in the peripheral blood of AD patients.
- To explore the potential link between myeloid progenitor levels and AD pathogenesis.
Main Methods:
- Peripheral blood samples were collected from 10 individuals with AD and 10 healthy controls.
- Flow cytometry was used to measure Lin-CD117+CD34+FceRI+ cells.
- Total serum IgE levels were measured and correlated with myeloid progenitor counts.
Main Results:
- A significant increase in myeloid progenitors was observed in participants with AD compared to healthy controls (P = .0067).
- Total serum IgE levels did not show a correlation with myeloid progenitor counts.
- This study represents the first examination of this specific cell type in AD.
Conclusions:
- Findings suggest increased egress of myeloid progenitors from the bone marrow in AD patients.
- Myeloid progenitors may play a significant role in the pathogenesis of atopic dermatitis.
- Further research is warranted to elucidate the precise role of these cells in AD.
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