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Related Experiment Video

Updated: Sep 14, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Hyper-IgE syndrome: A rare case report.

Lee Smith¹, Ahmed Rafei², Susanna Caminada³

¹Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, United Kingdom.

The Journal of Allergy and Clinical Immunology. Global

|July 23, 2025

Summary

This summary is machine-generated.

Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency. This case highlights diagnostic challenges and the need for timely identification of HIES for effective symptom management.

Keywords:

HIES Hyper-IgE syndrome IgE Job syndrome

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Last Updated: Sep 14, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Detection of True IgE-expressing Mouse B Lineage Cells

Detection of True IgE-expressing Mouse B Lineage Cells

Published on: December 1, 2014

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Area of Science:

Immunology
Genetics

Background:

Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency.
Characterized by atopic dermatitis, recurrent infections, and high IgE levels.

Observation:

Diagnosis of HIES is challenging due to its rarity and nonspecific presentation.
Can be misdiagnosed with conditions like cystic fibrosis or tuberculosis.

Findings:

A 30-year-old female patient with a history of long-term misdiagnosis of HIES is presented.
This case underscores the diagnostic complexities associated with HIES.

Implications:

Highlights the need for increased awareness and improved diagnostic strategies for HIES.
Emphasizes the importance of accurate diagnosis for appropriate symptom management and complication avoidance.