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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Natriuretic Peptides (BNP)
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Related Experiment Video

Updated: Sep 14, 2025

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
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Decorin levels and cardiometabolic function after endurance exercise.

Antônio Alves de Fontes-Junior1, Cesar Augustus Zocoler de Sousa1, Leandro Barbosa de Oliveira1

  • 1Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil.

Frontiers in Physiology
|July 23, 2025
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Summary

Endurance exercise increases decorin levels, a protein vital for muscle repair. Higher decorin concentrations in runners correlate with better exercise performance and distinct cardiorespiratory profiles.

Keywords:
decorinexercisemetabolismmyokineperformance

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Area of Science:

  • Exercise physiology
  • Biochemistry
  • Cardiology

Background:

  • Decorin is secreted by muscle cells during exercise, aiding in muscle repair and regeneration.
  • Its role in cardiometabolic function following endurance exercise requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between decorin levels and cardiometabolic parameters after marathon running.
  • To explore how varying decorin concentrations influence exercise performance and physiological responses.

Main Methods:

  • Fifty-six male amateur runners (30-55 years) underwent cardiopulmonary exercise testing (CPET) before and after a marathon.
  • Plasma decorin levels were measured, and correlations with CPET data were analyzed.

Main Results:

  • Plasma decorin levels doubled post-marathon, correlating positively with peak VO2, maximum speed, and Oxygen Uptake Efficiency Slope (OUES).
  • Runners with higher decorin levels showed enhanced performance metrics, while those with lower levels had impaired OUES.

Conclusions:

  • Decorin levels are associated with key CPET parameters, indicating distinct cardiorespiratory profiles based on concentration.
  • Further research is needed to understand the influence of elevated decorin on cardiometabolic responses in athletes.