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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Copper-catalyzed direct regioselective C5-H alkylation reactions of functionalized indoles with α-diazomalonates

Tomohiro Isono1, Shingo Harada1, Mai Yanagawa1

  • 1Graduate School of Pharmaceutical Sciences, Chiba University Chuo-ku Chiba 260-8675 Japan Sharada@chiba-u.jp tnemoto@faculty.chiba-u.jp.

Chemical Science
|July 23, 2025
PubMed

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