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The 4BE quinqunx: A model for obesity pathogenesis
Sanjay Kalra1, Madhur Verma2, Nitin Kapoor3
1Department of Endocrinology, Bharti Hospital, Karnal, India; University Centre for Research & Development, Chandigarh University, Mohali, India.
Abstract:
For obesity management to be effective, one must appreciate its causes and consequences. To do so, the seemingly complex science of obesity must be made simpler. A model which helps us explain its causes, contributory factors, as well as potential corrective measures, is needed. We share the 4BE winged quincunx model of obesity etiopathogenesis. Four central players - the Brain, Bowel, Beta/alpha cell and Bulk (adipose tissue)- form a causative quadruple, with four wings- Environmental determinants, Endocrine factors, Enteric microbiome and Extraneous limitations. The centre of the quincunx is occupied, in a stylish manner, by the ABC of weight management: Attitude, Behaviour and Choices. The 4BE concept makes it easy for health care professionals to understand, and explain, obesity.
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