The 4BE quinqunx: A model for obesity pathogenesis.

Area of Science:

• Obesity Etiopathogenesis
• Medical Modeling
• Public Health

Background:

• Effective obesity management requires understanding its complex causes and consequences.
• Simplifying the science of obesity is crucial for practical application.
• A clear model is needed to explain obesity's origins, influences, and interventions.

Purpose of the Study:

• To introduce the 4BE winged quincunx model for obesity etiopathogenesis.
• To provide a simplified framework for understanding obesity.
• To facilitate comprehension and explanation of obesity for healthcare professionals.

Main Methods:

• Development of the 4BE winged quincunx model.
• Identification of four central players: Brain, Bowel, Beta/alpha cell, and Bulk (adipose tissue).
• Incorporation of four 'wings': Environmental determinants, Endocrine factors, Enteric microbiome, and Extraneous limitations.
• Positioning Attitude, Behaviour, and Choices (ABC) at the model's center.

Main Results:

• The 4BE model presents a structured approach to obesity.
• It categorizes key etiological factors and influences.
• The model integrates biological, environmental, and behavioral aspects of obesity.

Conclusions:

• The 4BE winged quincunx model offers a simplified yet comprehensive view of obesity.
• This model enhances the ability of healthcare professionals to understand and communicate obesity.
• It serves as a valuable tool for obesity management and education.