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Overview of Exosomes01:36

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
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Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
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Integrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis.

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Related Experiment Video

Updated: Sep 14, 2025

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

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Exosomes in Ocular Health and Disease.

Elie Beit-Yannai1

  • 1Clinical Biochemistry and Pharmacology Department, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Current Eye Research
|July 23, 2025
PubMed
Summary

Exosomes are key to eye communication and health. Research highlights their potential as diagnostic biomarkers and therapeutic agents for various ocular diseases.

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biotechnology

Background:

  • Exosomes, small extracellular vesicles (30-150 nm), are vital for intercellular communication in ocular tissues.
  • Understanding exosome biogenesis and function is crucial for ocular health and disease.

Purpose of the Study:

  • To review the roles of exosomes in ocular health and disease.
  • To explore exosome biogenesis, functions in eye structures, and potential as diagnostic biomarkers and therapeutic agents.

Main Methods:

  • Comprehensive review synthesizing current global research on ocular exosomes.
  • Integrated view of exosome biology in the eye.

Main Results:

  • Exosomes maintain retinal homeostasis, corneal function, and lens transparency.
Keywords:
Age-related macular degenerationcorneadrug deliveryexosomesglaucoma

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  • Exosomes are implicated in glaucoma, age-related macular degeneration, and diabetic retinopathy pathogenesis.
  • Exosomes show potential as early disease biomarkers and for targeted drug delivery, enhanced by microfluidics and nanotechnology.

    • Conclusions:

    • Ophthalmology exosome research offers promising diagnostic and therapeutic avenues.
    • Challenges in standardization, scalability, and clinical translation need addressing.
    • Overcoming challenges is key to realizing exosome potential for global ocular health.