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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Evaluation of inflammatory markers in pediatric patients with otitis media with effusion: a retrospective analysis
Agah Yeniceri1, Cetin Sahutoglu2, Ibrahim Sevim2
1Department of Otorhinolaryngology, University of Health Science, Ankara Bilkent City Hospital, Universiteler Neighborhood 1604thStreet No.9, Ankara, 06800, Turkey. agahyeniceri@gmail.com.
Insights
Inflammatory markers like SII, SIRI, and MLR may be linked to pediatric otitis media with effusion (OME), but their diagnostic value needs more research. Further studies are essential for understanding their role in OME management.
Area of Science:
- Pediatric Otolaryngology
- Immunology
- Hematology
Background:
- Otitis media with effusion (OME) is a prevalent pediatric condition impacting hearing and quality of life.
- Surgical intervention is common for OME, necessitating evaluation of associated factors.
Purpose of the Study:
- To assess the clinical significance of inflammatory markers in pediatric OME patients undergoing surgery.
- To compare inflammatory marker levels between OME patients and healthy controls.
Main Methods:
- Retrospective analysis of 1,121 pediatric patients (2-15 years), including 613 OME cases and 508 controls.
- Recorded complete blood count parameters, categorized effusion viscosity (serous/mucoid), and adenoid size.
- Utilized statistical methods for group comparisons.
Main Results:
- Significant differences in %LUC, SII, SIRI, and MLR between OME patients and controls (p<0.05).
- Higher SII, SIRI, MLR in OME group; higher %LUC in controls.
- No significant cut-off values from ROC analysis; %LUC differed significantly by adenoid grade (p=0.018).
- No correlation found between effusion viscosity and inflammatory markers.
Conclusions:
- Inflammatory markers show potential association with pediatric OME.
- Current clinical utility for diagnosis and follow-up remains uncertain.
- Prospective studies are required to clarify the role of these markers.
Purpose:
Otitis media with effusion (OME) is a common pediatric condition associated with hearing loss and reduced quality of life. This study aims to evaluate the clinical significance of various inflammatory markers in pediatric OME patients who have undergone surgical treatment.
Methods:
A retrospective analysis was conducted on 1,121 pediatric patients aged 2-15 years, including 613 OME patients who underwent tympanostomy tube placement (with or without adenoidectomy) and 508 healthy controls. Complete blood count parameters were recorded. Patients were divided into two groups based on the viscosity of intraoperative middle ear effusion as serous or mucoid and graded according to their adenoid sizes. Comparisons between groups were analyzed using appropriate statistical methods.
Results:
There was a significant difference in %LUC, SII, SIRI, and MLR values between the OME patients and the control group (p < 0.05). SII, SIRI, and MLR values were higher in the OME patient group, whereas %LUC was higher in the control group. ROC analysis did not yield significant cut-off values for any marker. Among adenoid grade groups, only %LUC showed a statistically significant difference (p = 0.018). There was no significant relationship between the viscosity of middle ear effusion and any of the inflammatory markers.
Conclusion:
The data suggest that inflammatory markers may be associated with OME; however, their clinical utility remains uncertain. Further prospective studies are needed to evaluate their potential role in the diagnosis and follow-up of at-risk pediatric patients.
