Related Experiment Video
Updated: Sep 14, 2025
05:06
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
Published on: July 14, 2023
1.9K
ASSOCIATIONS BETWEEN PREDOMINANT PERIPHERAL LESIONS AND SYSTEMIC COMPLICATIONS OF DIABETES MELLITUS
Ioanna Ploumi1, Xinyi Ding1, Francesco Romano1
1Harvard Retinal Imaging Lab, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; and.
Retina (Philadelphia, Pa.)
|July 23, 2025
Summary
Predominant peripheral lesions (PPL) in the eye are strongly linked to systemic vascular complications in diabetes mellitus (DM). Early detection of PPL may improve risk stratification and management of these severe conditions.
Area of Science:
- Ophthalmology
- Diabetology
- Cardiovascular Medicine
Background:
- Diabetes mellitus (DM) is a leading cause of microvascular and macrovascular complications.
- Predominant peripheral lesions (PPL) are retinal changes observed in diabetic patients.
- The association between PPL and systemic vascular complications requires further investigation.
Purpose of the Study:
- To investigate the relationship between predominant peripheral lesions (PPL) and systemic microvascular and macrovascular complications of diabetes mellitus (DM).
Main Methods:
- A cross-sectional, retrospective study analyzed 182 eyes from 100 diabetic patients using ultra-widefield color fundus photography (UWF-CFP).
- Presence and extent of PPL were assessed, and clinical data were collected.
- Generalized estimating equations were employed to analyze associations between PPL and systemic DM complications.
Main Results:
- Predominant peripheral lesions (PPL) were found in 37.9% of eyes.
- PPL presence and extent significantly correlated with peripheral arterial disease, coronary artery disease, and stroke.
- PPL were also associated with diabetic nephropathy and reduced estimated glomerular filtration rate.
Conclusions:
- A strong link exists between PPL and systemic vascular complications in diabetes mellitus.
- PPL may serve as an imaging biomarker for systemic vascular susceptibility.
- Early PPL detection can aid in risk stratification and proactive management of diabetic vascular complications.
Related Concept Videos
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
36
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
36
01:30Peripheral Artery Disease I: Introduction
34
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
34
01:15Diabetes: Symptoms, Diagnosis, and Complications
697
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
697
01:20Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
01:26Peripheral Artery Disease IV: Nursing Management
46
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
46
01:23Peripheral Artery Disease V: Postoperative Nursing Management
26
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
26