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Inflammatory Cell Immunophenotypes in Regressing Melanomas and Halo Nevi: Possible Keys to Distinguish Intensely
A Brugués1, G Roccuzzo2, A Garcia-Herrera3
1Melanoma Unit, Dermatology Department, University of Barcelona, Hospital Clínic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, España.
Actas Dermo-Sifiliograficas
|July 23, 2025
Summary
Halo nevi exhibit a stronger cytotoxic T-cell response and regulatory immune mechanisms compared to regressing melanomas. This finding aids in differentiating benign halo nevi from malignant melanomas.
Area of Science:
- Dermatopathology
- Immunology
- Oncology
Background:
- The tumor microenvironment of regressing melanomas and the inflammatory infiltrate in benign halo nevi are subjects of ongoing research.
- Understanding these immune profiles is crucial for insights into local immune responses, pathogenesis, and differential diagnosis.
Purpose of the Study:
- To compare the immunophenotypic profiles of inflammatory cells in benign halo nevi (Sutton nevi) and regressing melanomas.
- To identify potential markers for distinguishing between these challenging inflamed melanocytic tumors.
Main Methods:
- Histological analysis of 16 Sutton nevi and 70 regressing melanomas.
- Evaluation of inflammation density, location, fibrosis, and immune cell markers (CD3, CD4, CD8, CD25, FOXP3, PD1).
Main Results:
- Sutton nevi displayed higher inflammation density but similar fibrosis to melanomas.
- Sutton nevi showed higher CD8/CD3 ratios, while melanomas had higher CD4/CD3 and CD4/CD8 ratios.
- Increased CD25, FOXP3, and PD1 expression relative to CD4 was observed in Sutton nevi.
Conclusions:
- Halo nevi demonstrate a stronger cytotoxic reaction and a regulatory immune mechanism involving PD1, FOXP3, and CD25.
- These findings contribute to the characterization of halo nevi and regressing melanomas, offering clues for differential diagnosis.
