Quantitative ophthalmic posterior segment optical coherence tomography angiography and systemic conditions

Area of Science:

• Ophthalmology
• Medical Imaging
• Oculomics

Background:

• Optical coherence tomography angiography (OCTA) noninvasively images the eye's posterior segment microvasculature in 3D.
• OCTA is established for diagnosing and managing ocular conditions.
• Emerging applications include assessing systemic conditions across various medical fields.

Purpose of the Study:

• To explore the utility of OCTA in assessing systemic conditions.
• To identify associations between OCTA findings and systemic disease features.
• To highlight OCTA's role in the developing field of oculomics.

Main Methods:

• Quantitative analysis of retinal, optic nerve head, and choriocapillaris microvasculature using OCTA.
• Correlation of OCTA findings with systemic condition markers, severity, and prognosis.
• Review of existing literature on OCTA applications in systemic disease.

Main Results:

• OCTA findings correlate with clinically relevant features of systemic conditions.
• Associations include links to laboratory markers, disease severity, and prognosis.
• The study details known correlations between OCTA quantitative imaging and systemic health.

Conclusions:

• OCTA is a valuable tool for understanding the pathophysiology of systemic diseases.
• OCTA can identify potential biomarkers for the diagnosis, prognosis, and management of non-ocular conditions.
• These correlations support OCTA's role in oculomics for studying systemic health.