Association between time weighted average mechanical power normalized to compliance and prognosis of critically ill...

This study aims to evaluate the association of time‑weighted average mechanical power normalized to compliance (TWA-MP_CRS) with all-cause mortality to determine its value as a prognostic tool in intensive care patients.

Retrospective observational study.

Intensive care unit (ICU).

4387 first-time ICU-admitted patients in the Medical Information Mart for Intensive Care (MIMIC) IV.

None.

TWA-MP_CRS, ICU mortality and in-hospital mortality.

Participants' mean age was 61.4 ± 16.9 years and the median [IQR] baseline TWA-MP_CRS was 0.3 (0.2, 0.6) J/min/mL/cmH₂O. When TWA-MP_CRS was divided into quintiles (with quintile 1 representing the lowest values), after adjusting for covariates, the odds ratios [95% confidence intervals (CIs)] for ICU mortality were 1.49 (95% CI: 1.15-1.94), 1.67 (95% CI: 1.29-2.16), 1.79 (95% CI: 1.37-2.33), and 3.96 (95% CI: 3.01-5.21) for quintiles 2, 3, 4, and 5 respectively, with quintile 1 as reference. Similar results were found for hospital mortality.

Higher TWA-MP_CRS is associated with poor clinical outcomes in critically ill patients. Higher TWA-MP_CRS can lead to a higher mortality among ICU and in-hospital patients.