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Quercetin-Loaded Graphene Oxide Nanoparticles Modulate Inflammatory Gene Expression and Enhance Cell Migration In

Hossain Alipour1, Elnaz Tamjid1,2, Mehrdad Behmanesh1,3

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This study enhances quercetin

Keywords:
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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing Research

Background:

  • Quercetin, a flavonoid, has beneficial wound-healing properties.
  • Limited water solubility hinders quercetin's therapeutic application.
  • Graphene oxide (GO) offers a potential delivery system for enhanced efficacy.

Purpose of the Study:

  • To enhance quercetin's wound-healing potential by loading it onto graphene oxide (GO).
  • To evaluate the in vitro efficacy of quercetin-loaded GO for wound healing applications.

Main Methods:

  • Synthesis of GO and surface loading of quercetin.
  • In vitro cytotoxicity assessment on human foreskin fibroblasts.
  • Gene expression analysis (NF-κB, IL-1β, TNF-α) via qPCR.
  • Wound healing assessment using scratch assay.
  • Determination of Minimum Inhibitory Concentration (MIC) and Maximum Bactericidal Concentration (MBC) against E. coli and S. aureus.

Main Results:

  • Quercetin release was pH-dependent, with higher release at pH 8.5.
  • Quercetin-loaded GO demonstrated enhanced biocompatibility.
  • Significantly accelerated wound closure rates were observed with quercetin-loaded GO after 48 hours.
  • Quercetin-loaded GO exhibited potent antibacterial activity against both E. coli and S. aureus (MIC: 4.8 μg/mL).

Conclusions:

  • Quercetin-loaded GO formulation improves quercetin's efficacy and biocompatibility.
  • This novel nanocarrier shows significant potential for advanced wound healing therapies.
  • Quercetin-loaded GO represents a promising candidate for treating wounds with bacterial infections.