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Updated: Jul 1, 2026

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological
Norein Sakander1,2, Km Archana2,3, Ajaz Ahmed2,4
1Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine Jammu-180001 India.
Abstract:
An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The in vitro studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.
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