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Successful Management of Neonatal and Infantile Kaposiform Hemangioendothelioma with Low-Dose Sirolimus Therapy
Yoshimasa Uematsu1, Ken-Ichiro Konishi1, Kiyoshi Tanaka2
1Department of General-Pediatric Hepatobiliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Journal of Pediatrics. Clinical Practice
|July 24, 2025
Abstract:
Sirolimus is reportedly effective for kaposiform hemangioendothelioma. However, data on the efficacy of low-dose sirolimus therapy remain limited. This report presents two cases of neonatal and infantile kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon successfully treated with low-dose sirolimus (serum level: 2-6 ng/mL) without any adverse events.

