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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

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Published on: May 5, 2018

Association between obesity and cardiac conduction defects.

Mohamed A Mostafa¹, Jeff A Kingsley¹, Elsayed Z Soliman¹

¹Department of Cardiovascular medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.

Frontiers in Cardiovascular Medicine

|July 24, 2025

Summary

This summary is machine-generated.

High body mass index (BMI) is linked to an increased risk of cardiac conduction defects (CCD), particularly at-rioventricular block (AVB). This association is more pronounced in older individuals, men, and those with diabetes.

Keywords:

BMI UK biobank cardiac conduction defects heart block obesity

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Published on: June 21, 2016

Area of Science:

Cardiology
Public Health
Obesity Research

Background:

Limited literature exists on the connection between high body mass index (BMI) and cardiac conduction defects (CCD).
Obesity is a growing public health concern with potential cardiovascular implications.

Purpose of the Study:

To investigate the cross-sectional association between various BMI levels and the prevalence of cardiac conduction defects (CCD).
To identify specific subgroups within the population where this association may be stronger.

Main Methods:

Utilized data from 455,790 participants in the UK Biobank.
Defined CCD using ICD codes for atrioventricular block (AVB) or intraventricular block (IVB).
Employed multivariable logistic regression to analyze the relationship between BMI and CCD.

Main Results:

A 1-unit increase in BMI correlated with a 3% rise in CCD odds (OR 1.03).
Marked obesity (BMI >40) increased CCD odds by 20% compared to normal BMI.
The association was significantly stronger in older adults, men, and individuals with diabetes.

Conclusions:

Elevated BMI is associated with an increased risk of CCD, primarily driven by AVB.
Interventions targeting weight management in obese individuals may reduce CCD risk, warranting further investigation.