Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K
Aging01:26

Aging

185
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
185
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

262
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
262
Bone Disorders01:29

Bone Disorders

4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Drug Therapy01:28

Drug Therapy

100
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
100
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[ICE WATER IMMERSION - RISK OR RESILIENCE?]

Harefuah·2024
Same author

The Physical Activity Vital Sign for Older Adults: Time for an Update.

Journal of the American Medical Directors Association·2024
Same author

Response to Letter to the Editor.

Current sports medicine reports·2023
Same author

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity.

Current sports medicine reports·2023
Same author

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity.

Current sports medicine reports·2021
Same author

Remote ischemic preconditioning improves tissue oxygenation in a porcine model of controlled hemorrhage without fluid resuscitation.

Scientific reports·2021
Same journal

[Tennis Elbow Among Players].

Harefuah·2026
Same journal

[Internal Medicine - My Mission].

Harefuah·2026
Same journal

[Treatment of Morbid Obesity in Israel: GLP-1 Agonists Versus Bariatric Surgery - Clinical and Economic Aspects].

Harefuah·2026
Same journal

[Baby steps: Post-operative Treatment Recommendations for Pediatric Tracheostomy in Israel].

Harefuah·2026
Same journal

[Mastoiditis Caused by Fusobacterium Necrophorum: an Unusual Pathogen in a Well-Known Disease].

Harefuah·2026
Same journal

[Cochlear Implantation in Single-Sided Deafness - Six Years of Follow-Up from Diagnosis and Consistent Use, Through Dedicated and Creative Auditory Learning, to the Development of Bilateral Central Processing Abilities].

Harefuah·2026
See all related articles

Related Experiment Video

Updated: Sep 14, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.2K

[SHOULD MEDICINE TREAT AGING AS A DISEASE?]

Yuval Heled1, Ayelet Shachar2

  • 1Faculty of Science, the Program of Physical Activity and Health, Kibbutzim College, Tel Aviv, Israel, The National Institute of Sports Medicine, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Harefuah
|July 24, 2025
PubMed
Summary
This summary is machine-generated.

Aging is a complex biological process, not a disease. Understanding aging mechanisms may help delay age-related diseases, but defining aging as a disease presents significant medical and regulatory challenges.

More Related Videos

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.5K

Related Experiment Videos

Last Updated: Sep 14, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.2K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.5K

Area of Science:

  • Gerontology
  • Biogerontology
  • Pathology

Background:

  • Aging is a universal biological process impacting all bodily systems.
  • Chronic diseases like cardiovascular, diabetes, and neurodegenerative conditions are closely linked to aging.
  • A paradigm shift views aging mechanisms as a pathological process that promotes disease development.

Purpose of the Study:

  • To explore the complex question of whether aging should be medically classified as a disease.
  • To review biological mechanisms of aging and their link to chronic diseases.
  • To examine the potential for direct anti-aging interventions and associated challenges.

Main Methods:

  • Review of established biological aging mechanisms.
  • Analysis of the relationship between aging and common chronic diseases.
  • Discussion of current therapeutic strategies targeting aging processes.
  • Examination of the definitional and regulatory hurdles for classifying aging as a disease.

Main Results:

  • Aging is a fundamental biological process, not currently defined as a disease.
  • Intervening in aging mechanisms shows potential to delay or prevent age-related diseases.
  • Significant challenges exist in defining aging as a disease, including establishing clear medical indications.

Conclusions:

  • While aging itself is not a disease, understanding its mechanisms is crucial for combating age-related pathologies.
  • Future medical approaches may focus on targeting aging processes to improve healthspan.
  • Classifying aging as a disease requires further scientific consensus and regulatory consideration.