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Sleep disorders in patients with differentiated thyroid cancer: a case-control study
Yuenan Zheng1, Yang Shi1, Qingshu Wu1
1Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, P. R. China.
Endocrine
|July 24, 2025
Summary
Differentiated thyroid cancer (DTC) patients experience higher rates of sleep disorders, affecting over 50%. Unemployment, anxiety, and depression are key risk factors for poor sleep quality in these survivors.
Area of Science:
- Oncology
- Sleep Medicine
- Psychiatry
Background:
- Thyroid cancer survivors often face sleep disturbances, impacting their quality of life.
- Differentiated thyroid cancer (DTC) is the most common type of thyroid cancer.
Purpose of the Study:
- To compare sleep quality between DTC patients and healthy individuals.
- To identify risk factors associated with sleep disorders in DTC survivors.
Main Methods:
- A case-control study involving 318 DTC patients and 72 healthy controls.
- Utilized the Pittsburgh Sleep Quality Index (PSQI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS).
- Employed chi-square, Mann-Whitney, and logistic regression analyses.
Main Results:
- Sleep disorders were significantly more prevalent in DTC patients (50.3%) than controls (34.7%).
- DTC patients showed significant differences in sleep disturbances and daytime dysfunction.
- Unemployment, anxiety, and depression were independent predictors of sleep disorders in DTC patients.
Conclusions:
- DTC patients have a high susceptibility to sleep disorders.
- Clinicians should screen DTC patients for unemployment, anxiety, and depression to address sleep quality.
- Interventions like information support and multidisciplinary consultations can improve well-being.
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