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Updated: May 2, 2026

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RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular

Richard Shaw1, Ruth Knight2, Ayten Basoglu2

  • 1Liverpool Head & Neck Centre, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK. rjshaw@liv.ac.uk.

Trials
|July 24, 2025
PubMed
Summary

The RAPTOR trial investigates PENTOCLO for mandibular osteoradionecrosis (ORN), a severe radiation side effect. This study will offer initial evidence on PENTOCLO

Keywords:
CancerClinical trialHead and neckMandibleOsteoradionecrosisPENTOCLOPentoxifyllineRadiotherapySodium clodronateTocopherol

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