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Updated: Sep 14, 2025
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted
Guofeng Yi1, Jiayi Li1, Qiqi Xu1
1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. wy_wjs@163.com.
Abstract:
We develop a unique trident-like multi-cationic photosensitizer (PS) with an acceptor-donor-acceptor (A-D-A) structure to enhance photodynamic therapy (PDT). The design minimizes PS leakage from membrane camouflaged nanoparticles (<1% in 24 h) via hydrophilic anchoring, while boosting ROS generation (13.8-fold higher 1O2 than Rose Bengal) through excited state optimization, thus significantly improving tumor-targeted PDT efficiency.
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