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Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
Published on: June 10, 2022
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Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment.
Qiancheng Gu1,2, Huaqian Xue1, Zhiyun Liu1,2
1Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 25, 2025
Summary
Biomaterials offer advanced delivery for lung disease therapies, protecting messenger RNA (mRNA) and improving treatment efficacy. This review explores biomaterial applications and future directions for mRNA-based lung disease treatments.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pulmonology
Background:
- Lung diseases represent a significant global health burden requiring innovative therapeutic strategies.
- Biomaterials have emerged as a promising platform for targeted drug delivery in respiratory medicine.
- Messenger RNA (mRNA) therapeutics offer advantages in biosafety, controllability, and translation for treating lung conditions.
Purpose of the Study:
- To review the role of biomaterials in enhancing drug delivery for lung diseases.
- To evaluate the impact of lung structure on drug absorption and delivery mechanisms.
- To explore the application of biomaterials in stabilizing and delivering mRNA for lung disease therapy.
Main Methods:
- Comprehensive literature review of biomaterials used in drug delivery for lung diseases.
- Analysis of various biomaterial types, including nanoparticles (liposomes, polymers, exosomes, etc.).
- Evaluation of chemical modifications for improved biomaterial performance (e.g., endosomal escape, targeting).
Main Results:
- Biomaterials demonstrate excellent biocompatibility and protect therapeutic agents from degradation.
- Nanoparticles enhance cellular uptake via endocytosis, with modifications improving targeting and delivery efficiency.
- Biomaterials are effective in stabilizing and protecting mRNA, crucial for advancing mRNA-based therapeutics.
Conclusions:
- Biomaterials provide a robust platform for targeted mRNA delivery in lung disease treatment.
- Further research into biomaterial-lung interactions and clinical translation is essential.
- This review offers a theoretical foundation and practical guidance for developing biomaterial-based mRNA therapies for lung diseases.
