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Related Experiment Video

Updated: Sep 13, 2025

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Computational Fluid Dynamics Simulations to Personalize Nasal Irrigations.

Thomas Radulesco1,2, Dario Ebode1,2, Ralph Haddad2

  • 1IUSTI Laboratory, Centre National de la Recherche Scientifique (CNRS), Aix Marseille University, 13001 Marseille, France.

Journal of Personalized Medicine
|July 25, 2025
PubMed
Summary

Head position significantly impacts nasal irrigation effectiveness. Tilting the head right improves saline solution delivery to the maxillary sinus, while upright positions offer less sinus coverage.

Keywords:
computational fluid dynamicsnose and paranasal sinusesrhinology

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Area of Science:

  • Biomedical Engineering
  • Computational Fluid Dynamics
  • Rhinology

Background:

  • Effective nasal irrigation is crucial for managing sinonasal conditions.
  • Technique influences drug delivery and patient comfort.
  • Understanding fluid dynamics in the nasal cavity is key.

Purpose of the Study:

  • To evaluate the effect of different head positions on saline distribution.
  • To analyze fluid dynamics in the nasal cavity and maxillary sinus.
  • To optimize nasal irrigation techniques using computational fluid dynamics (CFD).

Main Methods:

  • CFD simulations performed on a CT-based model of a healthy adult.
  • 4 mL saline solution administered intranasally over three seconds.
  • Analysis of fluid distribution and mucosal coverage in nasal regions and maxillary sinus.

Main Results:

  • Upright position: primarily inferior/middle nasal regions, minimal sinus penetration.
  • Right-tilted position: improved maxillary sinus coverage and inferior nasal irrigation.
  • Left-tilted position: enhanced central nasal coverage, slight sinus improvement.

Conclusions:

  • Head position is a significant factor in nasal irrigation outcomes.
  • Specific head tilts can enhance targeted delivery to the maxillary sinus.
  • Findings can inform clinical practice for nasal irrigation protocols.