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Toxic Metal Content in Deciduous Teeth: A Systematic Review
Ireneusz Zawiślak1, Sylwia Kiryk2, Jan Kiryk3
1Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Józefa Chełmońskiego 37, 51-630 Wroclaw, Poland.
Toxics
|July 25, 2025
Summary
Deciduous teeth reveal chronic toxic metal exposure from fetal development. Environmental and individual factors influence metal accumulation, impacting health and potentially aiding research into diseases like autism.
Area of Science:
- Environmental Health
- Toxicology
- Pediatrics
Background:
- Deciduous teeth serve as a stable biological matrix for assessing chronic toxic metal exposure during early life stages.
- Metal accumulation in teeth is influenced by environmental factors (e.g., industrialization, mining) and individual factors (e.g., maternal diet, smoking).
Purpose of the Study:
- To evaluate toxic metal content in deciduous teeth.
- To identify factors contributing to toxic metal accumulation.
- To explore potential health implications of toxic metal exposure.
Main Methods:
- A systematic review was conducted following PRISMA guidelines and PICO framework.
- Literature search performed in PubMed, Scopus, and Web of Science databases.
- Quality assessment using Joanna Briggs Institute (JBI) checklist; 20 studies included.
Main Results:
- Higher toxic metal levels, particularly lead, found in children from industrial areas, mining sites, or conflict zones.
- No definitive link established between secondhand smoke and lead/cadmium levels.
- Lower manganese levels associated with autistic traits and cognitive deficits.
Conclusions:
- Deciduous teeth are valuable for assessing chronic prenatal and early postnatal toxic metal exposure.
- Findings can inform research on diseases of unknown etiology, such as autism.
- This research has potential clinical significance for disease prevention and treatment, and for monitoring environmental pollution.
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