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Biotransformation research advances - 2024 year in review
Lionel Cheruzel1, Upendra A Argikar2, Pietro Brunetti3
1Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Drug Metabolism Reviews
|July 25, 2025
Summary
This annual review highlights key research in biotransformation, covering drug metabolism, enzymatic processes, novel models, gut microbiota, and enzyme activity modulation. It presents 16 selected manuscripts with expert commentary.
Area of Science:
- Pharmacology and Drug Metabolism
- Biochemistry
- Microbiology
Background:
- Annual review series focusing on significant advancements in biotransformation research.
- Biotransformation is critical for drug development and understanding physiological processes.
Purpose of the Study:
- To curate and present significant research articles in the field of biotransformation.
- To provide expert synopsis and commentary on 16 selected manuscripts.
- To cover diverse areas including drug metabolism, enzymatic activity, and microbiota roles.
Main Methods:
- Literature review and selection of 16 impactful manuscripts.
- Synopsis and critical commentary preparation.
- Categorization of research into five key areas.
Main Results:
- Compilation of 16 significant manuscripts in biotransformation.
- Detailed synopses and commentary provided for each manuscript.
- Research is organized into five thematic areas for clarity.
Conclusions:
- The review consolidates critical findings in drug metabolism and biotransformation.
- It highlights emerging trends and important research directions in the field.
- The collection serves as a valuable resource for researchers in pharmacology and related disciplines.
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