Human Breast Milk-Derived Extracellular Vesicles Enhance Osteoblast Activation via BMP2/MAPK Signaling Pathways
Jae-Hee Kwon1, Hayeon Jang1, Ji-Su Kim1
1Department of Food and Nutrition, Andong National University, Andong, South Korea.
Journal of Medicinal Food
|July 25, 2025
Summary
Human breast milk-derived extracellular vesicles (HMEVs) promote bone cell growth and mineralization, suggesting a potential role in preventing and treating osteoporosis.
Area of Science:
- Biochemistry
- Cell Biology
- Osteology
Background:
- Human breast milk-derived extracellular vesicles (HMEVs) possess diverse physiological roles.
- Limited research exists on HMEVs' impact on bone growth and remodeling.
- Osteoporosis necessitates novel therapeutic strategies.
Purpose of the Study:
- To investigate the effects of HMEVs on osteoblast differentiation and mineralization.
- To explore the potential of HMEVs in osteoporosis prevention and treatment.
Main Methods:
- Assessing osteoblast proliferation, differentiation, and mineralization in response to HMEVs.
- Analyzing the expression of bone formation-related genes and proteins.
- Investigating the involvement of bone morphogenetic protein 2 (BMP2) and mitogen-activated protein kinase (MAPK) signaling pathways.
Main Results:
- HMEVs significantly promoted osteoblast proliferation, differentiation, and mineralization.
- Increased expression of bone formation markers was observed.
- BMP2 and MAPK signaling pathways were identified as mediators of HMEV effects.
Conclusions:
- HMEVs enhance osteoblast activity through BMP2 and MAPK signaling.
- HMEVs show promise for the prevention and treatment of osteoporosis.
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