A Proof-of-Concept Study Investigating the Effects of Transcranial Plus Intranasal Photobiomodulation on Cognitive...

Area of Science:

• Neuroscience
• Biomedical Engineering

Background:

• Repetitive head acceleration events (RHAEs) lack an effective rehabilitation standard.
• Cognitive impairments are a significant consequence of RHAEs.

Purpose of the Study:

• To investigate the efficacy of transcranial and intranasal photobiomodulation (PBM) for improving cognitive function.
• To assess PBM's impact on individuals with a history of RHAEs.

Main Methods:

• Forty-four participants with RHAE history received PBM treatment (810 nm LED headset and intranasal applicator) every other day for 8-10 weeks.
• Cognitive function was assessed using a comprehensive test battery before and after treatment.
• Data analyzed at group and individual levels using statistical tests and reliable change indices.

Main Results:

• Statistically significant group-level improvements were observed in fluid cognition, verbal learning/memory, attention, working memory, and executive functions.
• Individual-level analysis revealed reliable improvements in 0-36% of participants, particularly in attention and memory measures.
• Specific enhancements included improved verbal encoding, delayed recall, sustained attention, and cognitive switching.

Conclusions:

• Transcranial and intranasal PBM therapy appears to be a promising intervention for cognitive enhancement in individuals with RHAE history.
• PBM treatment may offer a novel approach for managing and preventing cognitive deficits associated with RHAEs.
• Further rigorous clinical trials are warranted to validate these findings and establish PBM as a standard treatment.