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Updated: Sep 13, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Cardiovascular risk stratification in an ethnically mixed population with type 1 diabetes mellitus: comparison of the
Isabella Cristina Paliares1, Patrícia Medici Dualib1, Priscila Maria Teixeira Aroucha1
1Department of Medicine, Division of Endocrinology, Universidade Federal de São Paulo, Estado de Israel, 639 Vila Clementino, São Paulo, SP 04022-001, Brazil.
Aim:
This study compared the performances of the Steno Type 1 Risk Engine (ST1RE) and the Scottish-Swedish risk model in a predominantly young and ethnically diverse type 1 diabetes (T1D) cohort.
Methods:
This retrospective study included 435 adults with T1D and no prior cardiovascular disease (CVD). The comparative performance of the models in predicting 10-year CV events was assessed using Kaplan-Meier analysis, ROC curves, the Hosmer-Lemeshow test, and Cohen's kappa coefficient.
Results:
Participants had a median age of 25 years (IQR: 21-32) and a T1D duration of 13 years (IQR: 9-18). The Scottish-Swedish model classified 75.2 % as low, 13.1 % as moderate, and 11.7 % as high risk. In contrast, the ST1RE classified 84.1 % as low, 10.8 % as moderate, and 5.1 % as high risk. Agreement between the models was moderate (κ = 0.550; 95 % CI: 0.468-0.632). Over a follow-up period of 9.2 years, 24 participants (5.5 %) experienced CV events. The C-statistic for the Scottish-Swedish model was comparable to that of the ST1RE (p = 0.986). Both models demonstrated good calibration.
Conclusions:
In this ethnically mixed and predominantly young T1D cohort, both the ST1RE and the Scottish-Swedish models demonstrated good discriminative ability and calibration for 10-year CV risk prediction.
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