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Updated: Sep 13, 2025

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
Published on: June 27, 2025
Gut microbiota shapes cancer immunotherapy responses
Wanting Lei1,2, Kexun Zhou3, Ye Lei4
1Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Abstract:
The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.
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