Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

7.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.1K
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

137
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
137

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Open-Geometry PET: Quantifying the Trade-off Between Time-of-Flight Resolution and Angular Coverage.

Physics in medicine and biology·2026
Same author

An Open Multi-Center Whole-Body FDG PET/CT Foundation Model for Tumor Segmentation.

ArXiv·2026
Same author

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Direct Cardiac T1 Mapping with Subspace Modeling and Free-breathing Data Acquisition.

IEEE transactions on bio-medical engineering·2026
Same author

Scan-wise generalized PET denoising with contrastive adversarial learning.

Physics in medicine and biology·2026
Same author

Individualized Treatment Effect Inference of Head and Neck Cancer with Multimodal Data.

APSIPA Transactions on Signal and Information Processing·2026

Related Experiment Video

Updated: Sep 13, 2025

MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

11.8K

In vivo 3D myocardial membrane potential mapping in humans using PET/MRI.

Felicitas J Bijari1,2, Paul Kyu Han1,2, Thibault Marin1,2,3

  • 1Yale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.

EJNMMI Research
|July 27, 2025
PubMed
Summary

This study introduces a novel PET/MR imaging technique for non-invasive 3D myocardial membrane potential mapping in humans. This advancement aids in diagnosing and monitoring cardiac diseases by visualizing mitochondrial function.

Keywords:
3DMagnetic resonance imagingMembrane potential mappingPositron emission tomography

More Related Videos

3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

8.9K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Related Experiment Videos

Last Updated: Sep 13, 2025

MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

11.8K
3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

8.9K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Area of Science:

  • Biophysics
  • Medical Imaging
  • Cardiology

Background:

  • Mitochondrial membrane potential is crucial for cardiac function and disease monitoring.
  • Current diagnostic methods for cardiac conditions can be improved with better functional imaging.

Purpose of the Study:

  • To develop and validate a non-invasive PET/MR imaging method for 3D myocardial membrane potential mapping in humans.
  • To assess the feasibility of visualizing mitochondrial function in the heart in vivo.

Main Methods:

  • Utilized [18F]-FTPP+ PET tracer with a bolus-plus-infusion protocol.
  • Performed dynamic cardiac PET/MR imaging and 3D cardiac T1 mapping for extracellular volume fraction.
  • Applied LTSA model for image reconstruction and kinetic modeling based on the Nernst equation for membrane potential calculation.

Main Results:

  • Successfully generated 3D myocardial membrane potential maps in three healthy subjects.
  • Achieved whole-heart membrane potential estimations, with values ranging from -144.7 ± 3.5 mV to -165.8 ± 3.1 mV.
  • Demonstrated the feasibility of the non-invasive PET/MR imaging approach for in vivo human studies.

Conclusions:

  • The developed PET/MR imaging method enables 3D myocardial membrane potential mapping in humans.
  • This technique holds potential for improved diagnosis and monitoring of cardiac diseases.