Related Experiment Video

Updated: Sep 13, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Transcription factor YBX1 orchestrates drug resistance and tumor progression in HCC

Dennis Kwabiah1, Veerababu Nagati2, Manish K Tripathi2

  • 1School of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA; Medicine and Oncology ISU, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.

Drug Discovery Today
|July 27, 2025
PubMed

Insights

Drug resistance causes most cancer deaths. This review explores Y-box binding protein 1 (YBX1) in hepatocellular carcinoma (HCC) and sorafenib resistance, identifying it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Drug resistance is a major cause of cancer mortality, particularly in hepatocellular carcinoma (HCC) treated with sorafenib.
  • Transcription factors (TFs) are critical in cancer development and treatment resistance.
  • Y-box binding protein 1 (YBX1) is implicated in aggressive cancers, but its role in HCC and sorafenib resistance is not well understood.

Purpose of the Study:

  • To review the role of Y-box binding protein 1 (YBX1) in hepatocellular carcinoma (HCC) progression.
  • To investigate YBX1's involvement in sorafenib resistance in HCC.
  • To explore YBX1 as a potential biomarker and therapeutic target for overcoming sorafenib resistance.

Main Methods:

  • Literature review of studies on YBX1 in cancer, focusing on HCC.
  • Analysis of molecular mechanisms underlying YBX1's function in cancer progression and drug resistance.
  • Evaluation of YBX1's potential as a prognostic biomarker and therapeutic target.

Main Results:

  • YBX1 is recognized as a regulator of aggressive traits in other cancers.
  • The specific role and mechanisms of YBX1 in HCC and sorafenib resistance require further elucidation.
  • YBX1 presents potential as a biomarker and therapeutic target.

Conclusions:

  • Y-box binding protein 1 (YBX1) plays a significant role in cancer progression and drug resistance.
  • Further research into YBX1's mechanisms in hepatocellular carcinoma (HCC) is warranted.
  • Targeting YBX1 may offer a strategy to overcome sorafenib resistance in HCC.
Keywords:
Y-box binding protein 1 (YBX1)drug resistancehepatocellular carcinomakinasesorafenib

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