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Updated: Sep 13, 2025

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
Published on: March 5, 2019
KDBI-RP: Kinetic Data of RNA-Protein Interactions Database
Yunpeng He1, Dongyue Hou1, Yuzong Chen2
1School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, China.
None:
Biomolecular interaction kinetics underpin essential cellular mechanisms, yet quantitative databases remain scarce for RNA-protein interactions (RPIs)-a critical regulatory axis in post-transcriptional control, synthetic biology, and therapeutic development. We previously established KDBI (Kinetic Data of Bio-molecular Interactions database) to catalog quantitative kinetics data across diverse biomolecular interaction types. Here, we present KDBI-RP, a dedicated extension focused on RPI kinetics, addressing the growing demand for RNA-centric kinetic research. KDBI-RP systematically integrates binding data for RNA-protein interactions, including kinetic rate constants-association (kon, 3657 entries) and dissociation (koff, 3761 entries)-supplemented by equilibrium dissociation constants (Kd, 175,932 entries). The database offers well-curated information on kinetic constants, assay conditions, literature sources, and comprehensive sequence, structural, and functional annotations for proteins, RNAs, and their complexes. KDBI-RP is freely accessible at http://www.kdbirp.aiddlab.com. We anticipate that KDBI-RP will serve as a valuable resource for the RNA biology and RNA-based medicine research communities.
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