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Updated: Sep 13, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Osteosarcoma
1Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; The Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21287, USA.
None:
The diagnosis of osteosarcoma can be challenging, given the diverse histologic patterns, limited biopsy samples, lack of tumor-specific molecular alterations, and necessity for radiologic correlation. This review summarizes the key pathologic features of osteosarcoma subtypes with an emphasis on illustrating radiologic, gross macroscopic, and histologic features to help pathologists with classification. In addition, the authors provide an update on recent advances in molecular genetics and summarize pertinent differential diagnoses.
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