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Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect
Lijun Chen1,2, Yuanyuan Zhou1, Yiyun Geng1
1School of Biotechnology and Food Engineering, Suzhou University of Technology, Suzhou 215500, China. yyzhou8601@126.com.
Abstract:
The natural flavanone hesperidin and its aglycone hesperetin were identified as human aldo-keto reductase family 1 member C1 (AKR1C1) and AKR1C2 inhibitors via chemoproteomic profiling, which provides mechanistic insight into their chemosensitization effects in cancer therapy.

