Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term prognosis of patients surviving progressive multifocal leukoencephalopathy.

Brain : a journal of neurology·2026

Same author

Education Research: Quality of Narrative Feedback Generated by a Large Language Model Compared With Expert Faculty for Case-Based Learning in Neurology Education.

Neurology. Education·2026

Same author

Incorporating fire severity mapping into fuel accumulation curves.

The Science of the total environment·2026

Same author

Could a macular telangiectasia type 2-like phenotype characterize retinal JC virus infection?

AIDS (London, England)·2026

Same author

Drought, topography, and forest management shape wildfire occurrence and severity in montane Australian landscapes.

The Science of the total environment·2025

Same author

JC Virus-Related Retinopathy.

JAMA ophthalmology·2025

Same journal

Animal empathy reconsidered: a multidimensional profile account.

Biological reviews of the Cambridge Philosophical Society·2026

Same journal

Dynamic molecular networks unveil the mechanism behind hypoxia-induced tumour cell dormancy.

Biological reviews of the Cambridge Philosophical Society·2026

Same journal

Kin discrimination in plants: overview and implications for population and community ecology.

Biological reviews of the Cambridge Philosophical Society·2026

Same journal

Review of the fauna associated with wild and farmed mussels and oysters in the Mediterranean.

Biological reviews of the Cambridge Philosophical Society·2026

Same journal

What drives animal responses to high severity fire? The role of functional traits.

Biological reviews of the Cambridge Philosophical Society·2026

Same journal

Partners or passengers? Revisiting the association between diatoms and aquatic animals.

Biological reviews of the Cambridge Philosophical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Inhibitory control tests in non-human animals: validity, reliability, and perspectives.

Louise Loyant¹, Luke Collins¹, Marine Joly¹

¹Department of Psychology, Centre for Comparative and Evolutionary Psychology, University of Portsmouth, King Henry Building, King Henry 1 Street, Portsmouth, PO1 2DY, UK.

Biological Reviews of the Cambridge Philosophical Society

|July 28, 2025

Summary

This summary is machine-generated.

Inhibitory control, crucial for goal-directed behavior, is poorly understood in animals due to unreliable tests. This review addresses challenges and proposes a framework for valid measurement and evolutionary study of this cognitive ability.

Keywords:

animal cognition battery of tasks behavioural inhibition cognitive control executive control motor regulation response inhibition self‐control

More Related Videos

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Related Experiment Videos

Last Updated: Jul 1, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Area of Science:

Animal Cognition
Neuroscience
Behavioral Ecology

Background:

Inhibitory control is vital for goal-directed behavior, with links to brain size and fitness in animals.
Current methods for measuring animal inhibitory control lack validity and reliability, hindering research.
The evolutionary drivers and nature of inhibitory control variation across species remain unclear.

Purpose of the Study:

To review conceptual and methodological challenges in studying animal inhibitory control.
To propose tools and a framework for valid and reliable measurement of inhibitory processes.
To outline requirements for studying the evolutionary underpinnings of inhibitory control.

Main Methods:

Literature review of existing research on animal inhibitory control.
Analysis of conceptual and methodological limitations in current paradigms.
Synthesis of approaches for developing valid and reliable measurement tools.

Main Results:

Identified significant challenges in the validity and reliability of existing animal inhibitory control tasks.
Highlighted the need for standardized methodologies and a unified framework for measurement.
Emphasized the importance of studying individual variation, heritability, and fitness consequences.

Conclusions:

Addressing methodological issues is crucial for advancing the study of animal inhibitory control.
A robust framework is needed to accurately assess inhibitory processes and their evolution.
Future research should focus on interspecies comparisons to understand the evolutionary pressures shaping this cognitive ability.