Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prodromal Association of Non-Motor Symptomatology in Adults With Neurodegenerative Diseases.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

"Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus for Tremor in Polr3a-Related Tremor-ataxia Syndrome: A Two-case Report".

Tremor and other hyperkinetic movements (New York, N.Y.)·2025
Same author

The costs and benefits of deep brain stimulation in Parkinson's disease: a review and social network analysis.

Arquivos de neuro-psiquiatria·2025
Same author

Contribution of Stroke to Long-Term All-Cause and Cause-Specific Mortality in Mexico City.

Neurology·2024
Same author

Ataxia due to a COQ8A Novel Variant in Primary Coenzyme Q10 Deficiency.

Movement disorders clinical practice·2023
Same author

Spastic Paraplegia Type 7 and Movement Disorders: Beyond the Spastic Paraplegia.

Movement disorders clinical practice·2022

Related Experiment Video

Updated: Jun 15, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K

Deep Brain Stimulation in Leigh-Like Syndrome Due to DNM1 Pathogenic Variant.

Leonel Villa-Villegas1, Luz Gabriela Lira-Jaime1, Katia Carmina Farías-Moreno1

  • 1Movement disorders and neurodegenerative diseases unit, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, México.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|July 28, 2025
PubMed
Summary

Globus pallidum deep brain stimulation (GPi-DBS) offers an effective treatment for disabling hyperkinesias in Leigh Syndrome Spectrum (LSS) patients. This intervention shows promise for long-term improvement in movement disorders stemming from mitochondrial defects.

Keywords:
Deep brain stimulationDynamin 1HyperkinesiasLeigh SyndromeLeigh-like syndromeMitofusin 2

More Related Videos

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.1K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.6K

Related Experiment Videos

Last Updated: Jun 15, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.1K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.6K

Area of Science:

  • Neurology
  • Genetics
  • Mitochondrial Biology

Background:

  • Leigh Syndrome Spectrum (LSS) encompasses genetic mitochondrial disorders causing diverse neurological issues, including movement disorders like chorea and dystonia.
  • Hyperkinetic movement disorders in LSS significantly impair patient quality of life, presenting a major clinical challenge.

Observation:

  • Mitochondrial disorders, including LSS, can lead to severe hyperkinesias, impacting patient mobility and daily functioning.
  • Globus pallidus deep brain stimulation (GPi-DBS) is an established surgical intervention for managing hyperkinetic movement disorders such as chorea and dystonia.

Findings:

  • GPi-DBS has demonstrated effectiveness in treating hyperkinesias associated with mitochondrial defects.
  • Specifically, patients with pathogenic DNM1-related mitochondrial disorders presenting with a Leigh syndrome phenotype may experience sustained improvement in hyperkinetic movements post-GPi-DBS.

Implications:

  • GPi-DBS represents a viable therapeutic option for managing debilitating hyperkinesias in LSS.
  • Further research into GPi-DBS for specific genetic mitochondrial disorders could refine treatment strategies and improve patient outcomes.