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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Updated: Sep 13, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

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Published on: February 21, 2025

Sex-Specific Associations Between Prebiotic Supplement Intake and Sarcopenia Risk: Evidence From NHANES.

Wenming Song¹, Jing Zhang¹, Yongxin Sha¹

¹Department of Chinese and Western Medicine Combined Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) Changde China.

Food Science & Nutrition

|July 28, 2025

Summary

This summary is machine-generated.

Prebiotic intake may reduce sarcopenia risk in women. This study found a significant inverse association in females, but not in males, suggesting a potential protective effect for women.

Keywords:

NHANES muscle health prebiotic supplements sarcopenia sex‐specific effects

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Area of Science:

Gerontology
Nutritional Science
Public Health

Background:

Sarcopenia, a decline in muscle mass and strength, is a major health concern.
Understanding modifiable risk factors like diet is crucial for prevention.

Purpose of the Study:

To investigate the sex-specific relationship between prebiotic consumption and sarcopenia risk.
To determine if prebiotics offer protection against sarcopenia in different sexes.

Main Methods:

Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
Defined sarcopenia using Foundation for the National Institutes of Health (FNIH) criteria (grip strength, muscle mass).
Analyzed 4463 adult participants (4306 nonconsumers, 157 consumers of prebiotics).

Main Results:

An inverse association was observed between prebiotic intake and sarcopenia risk in females (OR 0.11, p=0.01).
No significant association between prebiotic intake and sarcopenia risk was found in males.
Prebiotic consumption showed a potential protective effect specifically in women.

Conclusions:

Prebiotic intake may play a beneficial role in mitigating sarcopenia risk among adult women.
Further research is warranted to elucidate the mechanisms behind this sex-specific association.
Dietary interventions involving prebiotics could be a strategy for sarcopenia prevention in women.